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Showing posts with label DRUGS. Show all posts
Showing posts with label DRUGS. Show all posts

Sunday, 3 June 2018

CISPLASTIN

CISPLATIN

Cisplatin is  a heavy metal complex containing an atom of platinum in he center surrounded by two ammonia molecules and two chloride atoms and it is platinum based chemotherapy drug used to treat various types of cancers.

Action and pharmacology:-
Cisplatin is thought to act by producing inter-strand and cross-links of cellular DNA in a similar manner  to bifunctional ALKYLATING AGENTS. It does not appear to be cell-cycle specific.

Half life :-25 to 49 minutes and terminal half life of 58 to 73 hours was calculated.

INDICATIONS:-METASTATIC TESTICULAR TUMORS
                            METASTATIC OVARIAN TUMOR
                           ADVANCED BLADDER CA

CONTRAINDICATION:-HYPERSENSITIVITY TO CISPLATIN OF OTHER Pt contains.
                                           pregnancy
                                            laction
                                              renal impairment
                                                hearing impirment
                                                  myelosuppression

ADMINISTRATION:-
NIDDLE OR INTRAVENOUS SETS CONTAINING ALUMINUM PARTS THAT MAY COME IN CONTACT WITH CISPLATIN SHOULD NOT BE USED FOR PREPARATION OR ADMINISTRATION. ALUMINUM REACTS WITH CISPLATIN CAUSING PERCIPITATE FORMATION AND A LOSS OF POTENCY.

DRUG INTERACTIONS:- Live vaccines (contraindicated)
                                                aspirin and alcohol (GI bleeding chances)
                                                   with ototoxic and nephrotoxic durgs.
SIDE EFFECTS :- Thinned or bittle hair
                                 loss of appetite or weight
                                 diarrhoea 
                                 nausea and vommitting 
                                 change in taste
                                  tingling sensation
                                 unusual bruising or bleeding 
                                 black,tarry stools 
                                 fever chills dizziness  or feeling of faintnesspain in back
                                 swelling of the feet 
                                 seizures 
                                 rash 
                                 shortness of breath
(Ref:- united biotech private limited)

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