CISPLATIN
Cisplatin is a heavy metal complex containing an atom of platinum in he center surrounded by two ammonia molecules and two chloride atoms and it is platinum based chemotherapy drug used to treat various types of cancers.
Action and pharmacology:-
Cisplatin is thought to act by producing inter-strand and cross-links of cellular DNA in a similar manner to bifunctional ALKYLATING AGENTS. It does not appear to be cell-cycle specific.Half life :-25 to 49 minutes and terminal half life of 58 to 73 hours was calculated.
INDICATIONS:-METASTATIC TESTICULAR TUMORS
METASTATIC OVARIAN TUMOR
ADVANCED BLADDER CA
CONTRAINDICATION:-HYPERSENSITIVITY TO CISPLATIN OF OTHER Pt contains.
pregnancy
laction
renal impairment
hearing impirment
myelosuppression
ADMINISTRATION:-
NIDDLE OR INTRAVENOUS SETS CONTAINING ALUMINUM PARTS THAT MAY COME IN CONTACT WITH CISPLATIN SHOULD NOT BE USED FOR PREPARATION OR ADMINISTRATION. ALUMINUM REACTS WITH CISPLATIN CAUSING PERCIPITATE FORMATION AND A LOSS OF POTENCY.
DRUG INTERACTIONS:- Live vaccines (contraindicated)
aspirin and alcohol (GI bleeding chances)
with ototoxic and nephrotoxic durgs.
SIDE EFFECTS :- Thinned or bittle hair
loss of appetite or weight
diarrhoea
nausea and vommitting
change in taste
tingling sensation
unusual bruising or bleeding
black,tarry stools
fever chills dizziness or feeling of faintnesspain in back
swelling of the feet
seizures
rash
shortness of breath
(Ref:- united biotech private limited)
